Evidence map›Paper›PMID 41472674›Full record

ArticleResearch square2025

Neuronal versus Glial CB2 Receptors: Insights from a Novel CB2-KO-eGFP Reporter Mouse Line.

Zheng-Xiong Xi, Emily Linz, Hai-Ying Zhang, Christopher Dunn, Guo-Hua Bi, Ewa Galaj, Maia Maras, Bruce Hope, Francisco Javier Rubio, Qing-Rong Liu

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zheng-Xiong XiNational Institute on Drug Abuse.ORCID 0000-0001-6482-8104
Emily LinzNational Institute on Drug Abuse.
Hai-Ying ZhangNational Institute on Drug Abuse.
Christopher DunnNational Institute on Drug Abuse.
Guo-Hua BiNational Institute on Drug Abuse.
Ewa GalajNational Institute on Drug Abuse.ORCID 0000-0002-7180-4378
Maia MarasNational Institute on Drug Abuse.
Bruce HopeNIDA / NIH.
Francisco Javier RubioNational Institute on Drug Abuse.
Qing-Rong LiuNational Institute on Aging, National Institutes of Health.ORCID 0000-0001-8477-6452

Funding

Cannabinoid CB1 and CB2 receptors and drug abuseZIADA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2023 to 2025
$3.1M
Intramural NIH HHS ZIA DA000633
6 · The paper itself

Abstract

The cannabinoid CB2 receptor (CB2R) has emerged as a promising therapeutic target for pain and central nervous system disorders, yet its brain expression has remained controversial due to low basal levels and the lack of reliable antibodies. Previous green fluorescent protein (GFP) reporter mouse lines have produced conflicting findings, possibly because GFP was either randomly inserted into the genome or placed in the 3'-untranslated region of the CB2R gene (

Indexed as

astrocytesCB2-KOCB2-KO-eGFPCB2 receptorGFP reportermicroglianeurons

Identifiers

PMID41472674
PMCPMC12747279

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.