ArticleFrontiers in immunology2025
A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Arbovirus infections, including dengue, Zika, and chikungunya, constitute significant global health threats. The epidemiology of these diseases is closely tied to the biology and ecology of the mosquito Methods: This study investigated the impact of these conditions on Results: Notably, mosquitoes fed on HFHS-fed mice showed reduced survival, altered lipid profile and a significant reduction in midgut and systemic ZIKV infection levels, which correlated with distinct transcriptomic alterations in genes related to gut metabolism and homeostasis. Discussion: These findings demonstrate that the host's metabolic state is a critical modulator of mosquito physiology, increasing mosquito mortality while reducing ZIKV infection levels. This highlights that host-centric factors, such as the rising prevalence of metabolic syndrome, are an overlooked variable that may have complex epidemiological consequences for arbovirus transmission by mosquitoes.
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