Evidence map›Paper›PMID 41472804›Full record

ArticleFrontiers in microbiology2025

Triclocarban exposure at environmentally relevant concentrations perturbs the gut microbiota and metabolic profile in

Ruinan Zhao, Pengyuan Liu, Yaoyang Wu, Hongyan Bi, Jiaoying He, Jie Zhang, Yanfu Qu, Xiaohong Chen, Zhuo Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruinan ZhaoThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Pengyuan LiuThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Yaoyang WuThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Hongyan BiThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Jiaoying HeThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Jie ZhangCollege of Fisheries, Henan Normal University, Xinxiang, China.
Yanfu QuHerpetological Research Center, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.
Xiaohong ChenThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.
Zhuo ChenThe Observation and Research Field Station of Taihang Mountain Forest Ecosystems of Henan Province, College of Life Sciences, Henan Normal University, Xinxiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The antibacterial agent triclocarban (TCC) poses a significant threat to aquatic ecosystems and its impact on amphibians remain poorly understood. Methods: Here, we investigated its acute and chronic effects on Rana taihangensis tadpoles at environmentally relevant concentrations (i.e., 5, 15 and 45 μg/L) using an integrated approach combining morphology, gut microbiome, and non-targeted metabolomic analyses. Results and Discussion: The acute toxicity tests for 96 h revealed that TCC had a lethal concentration (LC50) value of 169.863 μg/L for R. taihangensis tadpoles. Chronic exposure resulted in reduced body condition score across all the three TCC-treated groups compared to the control. Gut microbiome analysis revealed that TCC exposure significantly altered the community composition at both phylum (e.g., Pseudomonadota and Fusobacteriota) and genus (e.g.,

Indexed as

amphibiangut microbiotametabolomeRana taihangensistriclocarban

Identifiers

PMID41472804
PMCPMC12747674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.