Erectile dysfunction and cardiovascular-kidney-metabolic syndrome: Insights from the all of us research program.

Introduction: Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) risk factors and is a potential indicator for future CVD events, but ED's association with cardiovascular-kidney-metabolic (CKM) syndrome has not been systematically studied. Methods: This study used data from the Results: Of the 97,475 male participants in this study, 5,575 (5.7 %) had a documented baseline ED diagnosis. The highest prevalence by race was white individuals (7.2 %) and by age range was 75-80 (12.7 %). Participants with ED versus those without ED had a higher rate of CKM conditions including diabetes mellitus (T2DM) (19.3 % vs 7.3 %), hypertension (HTN) (47.6 % vs 18.8 %), chronic kidney disease (CKD) (10.3 % vs 2.8 %), heart failure (HF) (5.7 % vs 2.0 %), atherosclerotic cardiovascular disease (ASCVD) (3.0 % vs 1.3 %), and atrial fibrillation (AF) (7.3 % vs 2.5 %). Baseline prevalent ED was associated with higher risks of developing CKM conditions of CKD, HF, AF, ASCVD, and HTN but not the development of T2DM. Conclusion: A diagnosis of ED was significantly associated with both the prevalence and future development of cardiovascular and metabolic conditions, suggesting that ED assessment should be incorporated into routine cardiometabolic risk evaluation.