ArticleFrontiers in neurology2025
Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate the association between the monocyte-to-high density lipoprotein (HDL) cholesterol ratio (MHR) and the presence and severity of white matter hyperintensities (WMHs) in patients with migraine. Methods: A total of 153 patients diagnosed with migraine and 90 age- and sex-matched healthy controls were included. Serum monocyte and HDL levels, and MRI findings were evaluated. WMHs severity was graded using the Fazekas scale. Serum parameters were compared and evaluated between the patient and control groups. In addition, the relationship between migraine clinical characteristics and MHR levels was examined. Results: MHR values were significantly higher in migraine patients than in controls ( Conclusion: MHR appears to be a promising inflammatory biomarker reflecting cerebral microvascular changes in migraine patients, even among young adults. These results support the contribution of low-grade systemic inflammation to migraine-associated white matter lesions.
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