Evidence map›Paper›PMID 41473658›Full record

ArticleFrontiers in aging neuroscience2025

Dexmedetomidine ameliorates cognitive and affective deficits by modulating neuroinflammation and neurogenesis in an Alzheimer's disease mouse model.

Mai Li, Chanyuan An, Xin Wang, Minghe Ren, Shiyu Liu, Ruixin Chen, Yuyan Guo, Jun Wang, Yulang Fei, Dafei Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mai Li *Department of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, China.
Chanyuan An *Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Xin WangInstitute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Minghe RenInstitute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Shiyu LiuInstitute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Ruixin ChenInstitute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yuyan GuoDepartment of Radiation Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jun WangDepartment of Anesthesiology, Shaanxi Provincial Cancer Hospital, Xi'an, China.
Yulang FeiDepartment of Neurology, The First Affiliated Hospital of Nanyang Medical College, Nanyang, China.
Dafei MaGolden Horse Arts & Crafts Co., Ltd, Zhejiang, China.
Kaige MaInstitute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yuming ZhangDepartment of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) involves progressive cognitive decline and neuropsychiatric symptoms that are strongly linked to neuroinflammation and aberrant hippocampal neurogenesis. We examined whether dexmedetomidine (Dex), a clinically used selective α

Indexed as

Alzheimer’s diseasecognitiondexmedetomidineneurogenesisneuroinflammation

Identifiers

PMID41473658
PMCPMC12745436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.