ArticleNeuro-oncology advances
DIAPH3 is upregulated in high-grade gliomas and linked to chromosomal instability.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Abstract: BackgroundDiaphanous-related formin 3 (DIAPH3) is a member of the formin family, a group of proteins that regulate actin and microtubule dynamics. During mitosis, DIAPH3 localizes specifically to the centrosome. Its loss destabilizes microtubules and disrupts mitotic spindle polarity, leading to multipolar mitoses and abnormal chromosome segregation, which ultimately causes aneuploidy in daughter cells. Methods: We investigated Results: Conclusions: These findings confirm the role of DIAPH3 in chromosome segregation in clinical glioma samples and demonstrate its association with high-grade, poor-prognosis gliomas.
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