Evidence map›Paper›PMID 41473792›Full record

ArticleACS central science2025

Light-Regulated Agonists Spatiotemporally Activating the Vitamin D Receptor Mitigate Psoriasis-like Inflammation in Mice without Inducing Hypercalcemia.

Xavier Rovira, Alfonso Espada, Carme Serra, Juanlo Catena, Marc Lopez-Cano, Silvia Panarello, Elisabet Perez-Albaladejo, Howard Broughton, Leticia Cano, Hans Ajieren and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Xavier RoviraMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.ORCID https://orcid.org/0000-0002-9764-9927
Alfonso EspadaCentro de Investigación Lilly, SA, Avenida de la Industria 30, 28108 Alcobendas, Spain.ORCID https://orcid.org/0000-0002-8301-1201
Carme SerraMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Juanlo CatenaMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Marc Lopez-CanoPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Silvia PanarelloMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Elisabet Perez-AlbaladejoMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.ORCID https://orcid.org/0000-0002-1319-9552
Howard BroughtonCentro de Investigación Lilly, SA, Avenida de la Industria 30, 28108 Alcobendas, Spain.
Leticia CanoCentro de Investigación Lilly, SA, Avenida de la Industria 30, 28108 Alcobendas, Spain.
Hans AjierenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Sadid KhanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Paula Alvarez-MontoyaPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Lourdes MuñozMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Joan FontMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Ana TraperoMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.ORCID https://orcid.org/0000-0003-4526-7895
Pablo RiveroMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.
Yanrong LiDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Donghui MaDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Xianglin YinDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Yanfei L MaEli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.
Jeffrey A DodgeEli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.
Mingji DaiDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID https://orcid.org/0000-0001-7956-6426
Pedro IrazoquiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.ORCID https://orcid.org/0000-0003-0832-3739
Venkatesh KrishnanEli Lilly and Company, Lilly Corporate Center, Lilly Research Laboratories, Indianapolis, Indiana 46285, United States.
Amadeu LlebariaMCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Jordi Girona, 18, 08034 Barcelona, Spain.ORCID https://orcid.org/0000-0002-8200-4827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D receptor (VDR) activation has demonstrated beneficial effects on psoriasis. However, its crucial role in calcium metabolism limits clinical applications due to the risk of health-threatening dysregulation in serum calcium. In the present study, we have designed, synthesized, and biologically tested highly potent light-controllable VDR agonists containing a photoswitchable azobenzene moiety in the drug scaffold. The optimized molecule

Identifiers

PMID41473792
PMCPMC12746157

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.