Tetracycline Antibiotics Induce Biosynthesis of Pro-Inflammatory Metabolites in the Immunobiotic

Esther J Han, Jack G Ganley, Caitlin B Winner, Joon Soo An, Mohammad R Seyedsayamdost

Abstract read

In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Discovery and Biosynthesis of Sesquiterpene Polyketide Ester from an Atypical Terpene and Highly Reducing Polyketide Pathway.JACS Au · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Esther J HanDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Jack G GanleyDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Caitlin B WinnerDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Joon Soo AnDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID https://orcid.org/0000-0002-3282-5790

Mohammad R SeyedsayamdostDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID https://orcid.org/0000-0003-2707-4854

Funding

Behavior-based discovery of small-molecule modulators of neurochemical signaling pathways that underlie addictionR01DA056358 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher Fang-Yen, Niels Ringstad · 2022 to 2026

$3.0M

From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural ProductsR35GM152049 · NIGMS · PRINCETON UNIVERSITY · PI Mohammad R Seyedsayamdost · 2024 to 2026

$1.2M

NIDA NIH HHS R01 DA056358NIGMS NIH HHS R35 GM152049

6 · The paper itself

Abstract

The human gut microbiome consists of diverse microbes that communicate through small molecules. Numerous recent studies have demonstrated links between gut microbiota and host physiological processes; however, the underlying metabolites remain elusive in part because laboratory conditions do not replicate the native environment of these bacteria. Herein, we focused on

Identifiers

PMID41473794

DOI10.1021/acscentsci.5c00969

PMCPMC12746155

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.