Evidence map›Paper›PMID 41473795›Full record

ArticleACS central science2025

C‑Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH.

Dipanwita Banerjee, Lu Xiao, Pavitra S Thacker, Jayanta Kundu, Muthiah Manoharan, Eric T Kool

Abstract read
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Nucleobase Coordination With MgChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Ribosome Molecular Aging Shapes Translation Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Dipanwita BanerjeeDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Lu XiaoDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0003-1934-4711
Pavitra S ThackerDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Jayanta KunduAlnylam Pharmaceuticals, Cambridge, Massachusetts 02142, United States.
Muthiah ManoharanAlnylam Pharmaceuticals, Cambridge, Massachusetts 02142, United States.ORCID https://orcid.org/0000-0002-7931-1172
Eric T KoolDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0002-7310-2935

Funding

Transcriptome Analysis with RNA-Reactive ProbesR35GM145357 · NIGMS · STANFORD UNIVERSITY · PI ERIC T. KOOL · 2022 to 2026
$3.0M
NIGMS NIH HHS R35 GM145357
6 · The paper itself

Abstract

Nucleotides with a carbon substitution for heteroatoms are common in biological and therapeutic RNAs. Important examples include the C-nucleosides pseudouridine and

Identifiers

PMID41473795
PMCPMC12746151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.