Evidence map›Paper›PMID 41474553›Full record

ArticleeLife2025

JAK-STAT pathway activation compromises nephrocyte function in a

Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunpo Zhao *Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-7942-3406
Jianli Duan *Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, United States.
Hannah SeahCenter for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, United States.
Joyce van de LeemputCenter for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, United States.
Zhe HanCenter for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-5177-7798

Funding

New Drosophila, mouse, and human podocyte models to study HIV-APOL1-G1 associated chronic kidney diseasesR01DK140937 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$830k
Integrating Drosophila and human podocyte studies to discover APOL1 renal toxicity mechanism and therapeutic targetsR01DK120908 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHE HAN · 2022 to 2022
$348k
NIDDK NIH HHS R01 DK098410NIDDK NIH HHS R01-DK098410NIDDK NIH HHS R01 DK120908NIDDK NIH HHS R01 DK140937NIDDK NIH HHS R01-DK140937
6 · The paper itself

Abstract

Chronic kidney disease is a major health issue and is gaining prevalence. Using a

Indexed as

Diet, High-FatDrosophila melanogasterDrosophila ProteinsJanus KinasesRenal Insufficiency, ChronicSignal TransductionSTAT Transcription FactorsAnimalsDisease Models, AnimalFat BodyTranscription FactorsDrosophila ProteinsJanus KinasesSTAT Transcription FactorsTranscription FactorsUpd2 protein, Drosophilacell biologyD. melanogasterDrosophilaJAK-STATnephrocytePydslit diaphragmUpd2

Identifiers

PMID41474553
PMCPMC12755883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.