Evidence map›Paper›PMID 41474969›Full record

ReviewThe Journal of experimental medicine2026

The cribriform plate: A dynamic central nervous system-immune hub.

Collin J Laaker, Sophia M Vrba, Jenna M Port, Martin Hsu, Cameron M Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Collin J LaakerNeuroscience Training Program, University of Wisconsin-Madison , Madison, WI, USA.ORCID 0000-0001-8532-9427
Sophia M VrbaDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1679-8240
Jenna M PortDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-5968-7626
Martin HsuDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-1210-6497
Cameron M BaenenDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0001-2267-0772
Melinda HerbathDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-8403-582X
Thanthrige Thiunuwan PriyathilakaDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-9533-0701
Matyas SandorDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-6463-6807
Zsuzsanna FabryDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-4555-9732

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
Regulation of Neuroinflammation by Meningeal LymphaticsR01NS126595 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Zsuzsanna Fabry · 2022 to 2026
$2.3M
Graduate Training in Cellular and Molecular Pathogenesis of Human DiseasesT32GM135119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Zsuzsanna Fabry · 2020 to 2026
$2.2M
The role of lymphatic clearance in brain TBR01NS123449 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Matyas Sandor · 2022 to 2026
$2.0M
Neuroinflammation-induced lymphangiogenesis in the CNSR01NS108497 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI FABRY, ZSUZSANNA · 2018 to 2022
$1.9M
American Heart Association 915125NIGMS NIH HHS T32 GM135119NIGMS NIH HHS T32 GM140935NIH HHS NS123449NIH HHS NS126595NINDS NIH HHS R01 NS108497NINDS NIH HHS R01 NS123449NINDS NIH HHS R01 NS126595NINDS NIH HHS T32 NS105602University of Wisconsin-Madison T32GM135119University of Wisconsin-Madison T32GM140935University of Wisconsin-Madison T32NS105602
6 · The paper itself

Abstract

Olfactory nerve bundles exit the brain through the cribriform plate (CP) with a rich perineural microenvironment (cpPME). This microenvironment facilitates interactions between cerebrospinal fluid, blood vessels, bone marrow, and lymphatic vessels. The immune niche of the cpPME changes in response to inflammation caused by stroke, autoimmunity, infection, and Alzheimer's disease. Neuroinflammation at the CP results in dysfunction of olfaction that might have diagnostic value in neurological disorders. Additionally, the proximity of the CP to the nasal mucosa allows targeted therapeutic interventions. A thorough understanding of the cpPME is essential for designing innovative diagnostics and treatments for neuroinflammatory diseases.

Indexed as

Central Nervous SystemOlfactory NerveAnimalsHumansNeuroinflammatory Diseases

Identifiers

PMID41474969
PMCPMC13508270

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.