ArticleBMJ open2025
Association between the cumulative average triglyceride glucose-body mass index and glycaemic state transitions in adults with pre-diabetes: evidence from the CHARLS cohort.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe role of the triglyceride-glucose body mass index (TyG-BMI) in glycaemic state transitions among individuals with pre-diabetes remains unclear. This study explores the association between cumulative average TyG-BMI and the likelihood of regression to normoglycaemia or progression to diabetes.
methodsParticipants with pre-diabetes from the China Health and Retirement Longitudinal Study were included. Pre-diabetes was defined using American Diabetes Association criteria. Cumulative average TyG-BMI was calculated using data from 2011 and 2015. Ordinal logistic regression and restricted cubic spline (RCS) analyses were used to evaluate the association between cumulative average TyG-BMI and glycaemic transitions.
resultsA total of 556 participants (mean age 58.5 years; 45.9% male) were included; 350 (62.9%) remained pre-diabetic, 111 (19.96%) reverted to normoglycaemia and 95 (17.09%) progressed to diabetes. After adjustment for confounding factors, higher cumulative average TyG-BMI was significantly associated with lower odds of regression to normoglycaemia and higher odds of progression to diabetes (OR=0.50; 95% CI 0.33 to 0.62; p<0.001). The RCS analysis demonstrated a negative linear relationship between cumulative average TyG-BMI and glycaemic improvement (p for overall <0.001, p for nonlinear=0.149).
conclusionsHigher cumulative average TyG-BMI levels identify individuals with pre-diabetes who are less likely to revert to normoglycaemia and more likely to progress to diabetes, highlighting its value as a practical marker for early risk stratification and targeted clinical management of pre-diabetes.
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