Evidence map›Paper›PMID 41476217›Full record

ArticleJournal of nanobiotechnology2025

β-Carotene liposome-based responsive hydrogel inhibits palmitoylation to restore intracellular calcium homeostasis for effective periodontitis treatment.

Shun Huang, Menghan Li, Zishuo Cheng, Minyu He, Jiaju Deng, Danlan Zhang, Miao Tan, Shijia Ding, Haiping Wu, Lan Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shun Huang *The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Menghan Li *Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education) College of Laboratory Medicine Chongqing Medical University, Chongqing, 400016, P.R. China.
Zishuo Cheng *The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Minyu HeThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Jiaju DengThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Danlan ZhangThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Miao TanThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China.
Shijia DingKey Laboratory of Clinical Laboratory Diagnostics (Ministry of Education) College of Laboratory Medicine Chongqing Medical University, Chongqing, 400016, P.R. China.
Haiping WuThe Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China. cqmuwhp@163.com.
Lan HuangThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, P.R. China. lanhuang@hospital.cqmu.edu.cn.

Funding

2025 Chongqing Medical University Elite Postgraduate Cultivation Program BJRC202504Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau ) 2025GDRC001National Natural Science Foundation of China No. 82170989National Natural Science Foundation of China No. 82272432National Natural Science Foundation of China No. 82402750Sichuan Science and Technology Program 2024NSFSC1541The Natural Science Foundation of Chongqing CSTB2022NSCQ-MSX0794
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress is a key pathological mechanism in periodontitis. Our study demonstrates that the periodontitis microenvironment induces ER stress, leading to ER Ca

Indexed as

beta CaroteneCalciumLiposomesLipoylationPeriodontitisAnimalsEndoplasmic Reticulum StressHomeostasisHumansMetal NanoparticlesMiceMitochondriaReactive Oxygen SpeciesSilverbeta CaroteneCalciumLiposomesReactive Oxygen SpeciesSilverCalcium overloadEndoplasmic reticulum stressPeriodontitisS-palmitoylationβ-carotene

Identifiers

PMID41476217
PMCPMC12866009

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.