Evidence map›Paper›PMID 41476245›Full record

ArticleScientific reports2025

Understanding the mechanism of Crassocephalum crepidiodes (Benth.) S. Moore leaf antifibrotic activity using in vivo and in silico methods.

Akingbolabo Daniel Ogunlakin, Olubunmi Asaleye, Divine Sokoato Anejukwo, Odunayo Victoria Olusegun, Holiness Balogun, Peluola Olujide Ayeni, AyoOluwa Deborah Adeola, Gideon Ampoma Gyebi, Great Oluwamayokun Adebodun, Zainab Abiodun Molik and 7 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Akingbolabo Daniel OgunlakinPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria. gbolaogunlakin@gmail.com.
Olubunmi AsaleyePhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
Divine Sokoato AnejukwoPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
Odunayo Victoria OlusegunPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
Holiness BalogunPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
Peluola Olujide AyeniPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
AyoOluwa Deborah AdeolaPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.
Gideon Ampoma GyebiDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, P.O. Box 1334, Durban, 4000, South Africa.
Great Oluwamayokun AdebodunDepartment of Physiology, Babcock University, Ilisan Remo, Nigeria.
Zainab Abiodun MolikDepartment of Pharmacognosy, University of Ibadan, Ibadan, Nigeria.
Amel ElbasyouniDepartment of Molecular Biology and Biotechnology, Pan African University for Basic Sciences, Technology and Innovation (PAUSTI), Nairobi, Kenya.
Opeyemi Josphine AkinmureleDepartment of Pharmacognosy, Lead City University, Ibadan, Ibadan, Nigeria.
Abdullahi Adeyemi AdegokeDepartment of Pharmacognosy, University of Ibadan, Ibadan, Nigeria.
Ajibola David AdelakunDepartment of Pharmaceutical Sciences, University of Arizona, Arizona, USA.
Omolola OluwadaraProject Development and Design Department, Federal Institute of Industrial Research, Oshodi, Lagos State, Nigeria.
Dare Ezekiel BabatundeAnatomy Programme, Bowen University, Iwo, 232101, Nigeria.
Oluyomi Stephen AdeyemiPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, 232101, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 30% of women of reproductive age are affected by uterine leiomyomas (fibroids). In women of reproductive age, these benign tumours have been associated with a higher risk of developing type II diabetes and infertility, which can lead to significant mental stress. Cytogenic abnormalities and somatic mutations-particularly in transcription factors such as GATA2 and FOXPI-are being considered as potential biomarkers for early detection and management. There is a pressing need for safer and more effective therapeutic options with fewer adverse effects. Therefore, this study evaluated the antioxidant, α-amylase, and α-glucosidase enzymes inhibitory and ameliorative effects of Crassocephalum crepidiodes on monosodium glutamate (MSG)-induced uterine leiomyoma in albino rats and proposed their mechanisms of action using an in silico approach. The NO radical scavenging efficacy of the control used, quercetin, is comparable to that of an aqueous extract of C. crepidiodes leaves. The extract's ability to chelate iron (Fe

Indexed as

Plant ExtractsPlant Leavesalpha-AmylasesAnimalsAntioxidantsComputer SimulationFemaleMolecular Docking SimulationRatsSodium Glutamatealpha-AmylasesAntioxidantsPlant ExtractsSodium GlutamateCrassocephalum crepidiodesFOXP1GATA2Medicinal plantsUterine leiomyomas

Identifiers

PMID41476245
PMCPMC12864859

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.