ReviewACS omega2025
Interplay between Epigenetic and Transcription Factors Mediating Drug Resistance via Stem Cells in Breast Cancer.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Globally, breast cancer (BC) is the most prevalent cancer in women, and drug resistance is a foremost challenge in BC management that contributes to 90% of BC-related deaths. Drug resistance arises as cellular adaptation during treatment, but the underlying mechanisms remain complex and are not yet fully understood. Research studies have shown that most anticancer drugs are effective against the mass of tumor cells rather than Cancer Stem Cells (CSCs). They have the ability to become dormant upon exposure to anticancer drugs and acquire drug resistance over a period of time after silently modifying themselves to resist the drug environment. The maintenance of the stem cell phenotype is mostly driven by stem cell transcription factors (e.g., KLFs, Myc, ZEB2, RUNX1, TWIST1, OCT4, NANOG, FOXO3, SOX2, E2Fs, etc.), which are mediated by epigenetic changes in tumor cells at many levels. These recognized factors/pathways have been demonstrated to be promising therapeutic targets. Therefore, knowledge of epigenetics in regulating cancer stem cells via stem cell transcription factors may be a promising solution for the reversal of therapy-resistant BC. In this review, we emphasize stem cell transcription factors, cancer stem cells, and epigenetic regulation as critical drivers of drug resistance in BC.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.