ArticleBJA open2025
Kidney disease and cardiac surgery: marker, mediator, or both?
Article in BJA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Metabolic Conditioning for Renal Protection During Cardiopulmonary Bypass: A Narrative Review.Artificial organs · 2026Review
- Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac surgery places an enormous burden on the kidneys, and therefore, acute kidney injury (AKI) is a common postoperative complication. Pre-existing chronic kidney disease (CKD) is a strong predictor of cardiac surgery-associated AKI, in addition to the evidence of a bidirectional interaction where AKI also accelerates the progression of CKD and increases the risk of renal failure. While observational research links kidney dysfunction to prolonged hospital stays, morbidity, and mortality, the question remains whether AKI is a modifiable mediator or merely a perioperative risk predictor. Larger analyses, including that of Bille and colleagues, indicate that AKI drives the acceleration of CKD. These findings provide further evidence for systematic follow-up and early implementation of kidney-protective measures to optimise long-term renal function after cardiac surgery.
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Registered trials
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