Different beta-blockers for preventing arrhythmic events in patients with long QT syndrome: a network meta-analysis.

Objective: This study aims to compare the efficacy of different types of beta-blockers in preventing arrhythmias in patients with long QT syndrome (LQTS), and simultaneously analyze the relationship between dose and effect within each drug by incorporating dose as a continuous covariate. Methods: A systematic search was conducted in the electronic database, with the cutoff date set at July 20, 2025. The search scope was limited to observational studies that compared at least two drug strategies. A Bayesian arm random-effects network meta-analysis (NMA) was performed, in which the daily equivalent dose (mg/day) was included as a continuous covariate to explore the dose-response relationship. Results: This analysis included 5,692 patients with LQTS from 10 cohort studies. In LQT1, nadolol was superior to propranolol (RR = 0.59, 95% CI: 0.39-0.90) and had the highest probability of being the optimal treatment (SUCRA = 0.92). Dose-response trends for all drugs were non-significant (all Conclusion: Nadolol demonstrates significant and consistent clinical advantages in LQT1 patients and should be considered as first-line therapy for this subtype. In LQT2 patients, nadolol not only shows a superiority trend but also has a significant dose-effect relationship, supporting its clinical priority; in LQT3 patients, nadolol exhibits a significant dose-dependent risk reduction trend, though no statistically significant differences in efficacy were observed among all beta-blockers. Additionally, LQT3 patients should be cautious of the potential risks associated with atenolol.