ArticleFrontiers in medicine2025
Individual components and cumulative burden of metabolic syndrome are associated with higher disease activity and adverse outcomes in Crohn's disease.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Red Cell Distribution Width-Standard Deviation Is Associated with Cumulative Metabolic Burden but Not Independently with Metabolic Syndrome.Medicina (Kaunas, Lithuania) · 2026Observational
- Metabolic Disorders and Inflammatory Bowel Diseases: Unraveling Shared Pathways and Clinical Interactions.Metabolites · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: The impact of metabolic syndrome (MetS) and its components on Crohn's disease (CD) remains unclear. This study investigated how individual MetS factors and cumulative metabolic burden affect CD activity and outcomes. Methods: This retrospective study was conducted at a tertiary care hospital and encompassed a cohort of 376 hospitalized patients diagnosed with CD from 2015 to 2025. Linear, logistic, and Poisson regression models assessed correlations between MetS elements and clinical indicators, evaluating how their presence and number affected CD. Results: Thirty-six patients (9.6%) had MetS. Compared to non-MetS patients, those with MetS exhibited a significantly higher Simple Endoscopic Score for CD (10 vs. 7; Conclusion: The concurrent presence of multiple MetS elements can synergistically worsen the clinical course of CD. Management of these components is crucial for the long-term prognosis of CD.
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