SynthesisFrontiers in endocrinology2025
Efficacy and safety of insulin efsitora in type 2 diabetes: a meta-analysis of randomized controlled trials.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This meta-analysis aimed to evaluate the efficacy and safety profiles of insulin efsitora in the treatment of type 2 diabetes (T2D). Methods: We conducted a comprehensive systematic search across PubMed, the Cochrane Library, and Embase from database inception through September 11, 2025. The study included randomized controlled trials (RCTs) that directly compared insulin efsitora with once daily basal insulin in T2D patients. Primary outcomes assessed were changes in hemoglobin A1c (HbA1c) and body weight. Methodological quality and risk of bias were evaluated using the Cochrane Quality Assessment Tool. Data synthesis was performed using random-effects models to calculate risk ratios (RR) and mean differences (MD). Results: The meta-analysis incorporated six RCTs involving 4116 participants. Our findings revealed no statistically significant difference in HbA1c reduction between insulin efsitora and once daily basal insulins (MD: -0.04%; 95% CI: -0.10% to 0.02%; p = 0.78). Other outcomes, including change in body weight, body mass index changes, proportion of patients achieving HbA1c < 7%, change in fasting plasma glucose, and various hypoglycemia events (level 1, level 2, and level 3), as well as adverse events and serious adverse events, showed comparable results between the two treatments. Notably, insulin efsitora demonstrated superior performance in total daily insulin dose and time in range (70-180 mg/dL). Conclusions: Insulin efsitora demonstrates comparable efficacy and safety to once daily basal insulins in the management of T2D. However, given the limited number of RCTs available in the current evidence base, further large-scale clinical trials are warranted to validate these findings and establish more definitive conclusions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.