ReviewiScience2025
The unanticipated role of the glial-associated glucose-6-phosphatase system in brain homeostasis.
Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glucose-6-phosphatase (G6Pase) system is a multiprotein complex within the endoplasmic reticulum that enables glucose export during high energy demand. Although traditionally studied in peripheral tissues such as the liver, recent studies highlight its relevance in the central nervous system, particularly in astrocytes and specialized glial cells called tanycytes. This review explores emerging functions of the G6Pase system in cerebral glial cells and its putative role in the regulation of brain bioenergetics and energy balance. In astrocytes, G6Pase expression supports glucose uptake, ATP production, and endoplasmic reticulum Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.