Evidence map›Paper›PMID 41476962›Full record

ArticleFrontiers in immunology2025

Linlin Xu, Pingping Jiang, Yang Xiao, Hongling Wang, Hongbo Liu, Huoying Chen

Abstract readValidation Study
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linlin Xu *Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
Pingping Jiang *Department of Emergency Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
Yang XiaoDepartment of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
Hongling WangDepartment of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.
Hongbo LiuThe First Affiliated Hospital of Guilin Medical University, Guilin, China.
Huoying ChenDepartment of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disorder. However, current diagnostic methods remain limited, necessitating the exploration of non-invasive diagnostic markers with higher specificity. Methods: This study integrated two GEO expression datasets to identify differentially expressed genes (DEGs) specific to pSS (distinct from SLE) and applied LASSO, XGBoost, RF, and SVM-RFE algorithms to screen candidate genes. Correlation and interaction network analyses were performed, followed by construction and validation of a diagnostic nomogram. The model's differential diagnostic ability was validated in IgG4-RD, RA, SLE, and SSc cohorts. Additionally, candidate genes and the diagnostic model were experimentally validated using RT-qPCR in clinical samples. Results: Three candidate genes ( Conclusions:

Indexed as

Antigens, CDAntigens, Differentiation, T-LymphocyteLectins, C-TypeMachine LearningReceptors, ImmunologicSjogren's SyndromeAdultBiomarkersCD69 AntigensDiagnosis, DifferentialFemaleGene Expression ProfilingHumansMaleMiddle AgedAntigens, CDAntigens, Differentiation, T-LymphocyteBiomarkersCD69 AntigensLectins, C-TypeReceptors, ImmunologicTIGIT protein, humanbioinformaticsbiomarkersdiagnostic modelmachine learningprimary Sjögren’s syndrome

Identifiers

PMID41476962
PMCPMC12747951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.