ArticleInternational journal of endocrinology2025
Mechanism of Jianpixiaoke Recipe in Treating Type 2 Diabetes Based on Network Pharmacology and Molecular Docking.
Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Mechanism of Jianpixiaoke Recipe in Treating Type 2 Diabetes Based on Network Pharmacology and Molecular Docking.International journal of endocrinology · 2025Article
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Authors and funding
5 authors.
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Abstract
Objective: Using network pharmacology and molecular docking technology to analyze the potential mechanism of the Jianpixiaoke recipe (JPXK recipe) in the treatment of type 2 diabetes mellitus (T2DM). Method: This study searched and screened the active ingredients and corresponding T2DM-related targets of different herbs in JPXK recipe from multiple databases. Venn was used to screen the intersection targets of JPXK recipe targets and T2DM targets, and the intersection targets were imported into the STRING database to construct a PPI network. In addition, clustering and topology analysis were also used to analyze PPI networks. At the same time, a composite target network was constructed using Cytoscape software. Then, we further carried out GO and KEGG enrichment analysis on the targets and carried out molecular docking verification on key chemical ingredients and hub targets. Finally, the effect of this prescription on T2DM was verified through animal experiments. Result: This study screened a total of 366 targets for the JPXK recipe, 1886 T2DM-related targets, and 214 intersecting targets. The active ingredients of the JPXK recipe were quercetin, isorhamnetin, luteolin, berberine, kaempferol, etc. Potential hub targets were Conclusion: This study revealed the active ingredients and potential molecular mechanism of the JPXK recipe in the treatment of T2DM, which provides valuable experience in future clinical trials.
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