ReviewDrug design, development and therapy2025
SGLT2 Inhibitors in Combination Therapies for Tumors: A Novel Approach to Synergistic Treatment Strategies.
Review in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Metabolism and Immunity-Adapted Radiotherapy (M.I.A.R): A Conceptual Framework for Overcoming the Therapeutic Plateau in Clinical Radiotherapy.Current oncology (Toronto, Ont.) · 2026Review
- Review
- Glucagon-like peptide-1 and dual/triple receptor agonists in the treatment of metabolic dysfunction-associated steatotic liver disease: advances in mechanistic research.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, originally developed for glycemic control in type 2 diabetes, have shown potential therapeutic effects in cancer treatment. Studies suggest that SGLT2 inhibitors can suppress tumor growth and proliferation through the modulation of metabolic reprogramming in tumor cells, inhibition of tumor glucose uptake, and regulation of the tumor microenvironment. Recent studies have emphasized the potential benefits of combining SGLT2 inhibitors with conventional anticancer therapies, including chemotherapy (CT), immunotherapy, and targeted therapies. Several clinical trials are currently evaluating the safety and efficacy of these combinations. Both preclinical and clinical studies primarily explore the effectiveness of SGLT2 inhibitors in inhibiting tumor growth, reducing metastasis, and enhancing treatment outcomes. Identifying combination therapies with SGLT2 inhibitors could enable more personalized treatment selection and optimization. This review provides a comprehensive summary of the antitumor effects and underlying mechanisms of SGLT2 inhibitors when combined with conventional anticancer therapies, aiming to elucidate their emerging role in cancer treatment. Combination regimens involving SGLT2 inhibitors have the prospect to overcome certain limitations of monotherapy, offering promising clinical benefits and improving patient outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.