SynthesisFrontiers in pediatrics2025
The impact of red blood cell storage duration on clinical outcomes in pediatric cardiac surgery: a systematic review and meta-analysis.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The impact of red blood cell (RBC) storage duration during cardiopulmonary bypass (CPB) priming in pediatric cardiac surgery remains unclear. Objective: To evaluate whether RBC storage time affects perioperative outcomes in children undergoing cardiac surgery. Methods: We performed a systematic review and meta-analysis of studies comparing fresh vs. longer-stored RBCs for CPB priming in pediatric patients. Databases searched included PubMed, EMBASE, Cochrane Library, and Web of Science (through May 2025). Primary outcomes were mortality, infection/sepsis, respiratory complications, and multiple organ dysfunction syndrome (MODS); secondary outcomes included mechanical ventilation duration, ICU stay, and intraoperative lactate levels. Results: Ten studies (including one randomized controlled trial) were included. No significant differences were found between groups in any primary or secondary outcomes, except for a slightly shorter ICU stay in the fresh RBC group (mean difference = -1.08 days), with high heterogeneity. Conclusions: RBCs stored within standard durations appear safe for CPB priming in pediatric cardiac surgery. These findings support current transfusion practices and underscore the need for further high-quality randomized trials. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=1015198, PROSPERO CRD420251015198.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.