In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Christina A StamouliGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0009-0000-0200-6762 Alexander DegenerGroup of Computational Science for Health and Environment, Center for Environmental and Climate Science, Lund University, Lund, Sweden.ORCID 0009-0009-7179-5051 Efrain Cepeda-PradoGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0001-9781-3742 Andreas BruzeliusGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.
Emil AnderssonGroup of Computational Science for Health and Environment, Center for Environmental and Climate Science, Lund University, Lund, Sweden.ORCID 0000-0001-6523-4973 Jessica GiacomoniGroup of Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center and Lund Stem Cell Center, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0001-9898-8608 Aurélie Delphine VorgeatGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0009-0006-9449-3222 Srisaiyini KidnapillaiGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.
Oxana KlementievaGroup of Medical Spectroscopy, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0003-1782-050X Malin ParmarGroup of Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center and Lund Stem Cell Center, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0001-5002-4199 Victor OlariuGroup of Computational Science for Health and Environment, Center for Environmental and Climate Science, Lund University, Lund, Sweden.
Daniella Rylander OttossonGroup of Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center and MultiPark strategic neuroscience network, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0002-9270-3576 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Direct lineage reprogramming of glial cells to induced neurons has the potential for restoring brain circuits and function in neuronal disorders and states. We introduce three-dimensional (3D) human glia reprogramming into neurons with a GABAergic interneuron phenotype using stem cell-derived human glia. Single-nucleus RNA sequencing of the converted cells demonstrates distinct neuronal clusters within 2 weeks, including a parvalbumin (PV) cluster with high neuronal maturity and features of chandelier interneurons. A lineage trajectory analysis of the glia-to-neuron conversion reveals a distinct lineage pathway to PV chandelier fate, including various neuronal developmental stages and the establishment of synaptic machinery. This analysis reveals PV fate-important genes that are previously unknown to neural reprogramming with promising functional importance for future derivations. Our data demonstrate successful human glia conversion into interneurons with features of bona fide PV subtype and highlight the reprogramming trajectory with key transitional genes. This advancement holds promise for future human brain cell engineering and repair.
Indexed as
Cell LineageCellular ReprogrammingInterneuronsParvalbuminsCell DifferentiationGABAergic NeuronsHumansNeurogliaParvalbumins
Identifiers
PMID41477840
PMCPMC12757047
What Socratic holds
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LicenceCC BY-NC
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