Evidence map›Paper›PMID 41477845›Full record

ArticleScience advances2026

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells.

Shruti V Bendre, Yu Wang, Basel Hajyousif, Rajendra K C, Shounak G Bhogale, Dhanya Pradeep, Natalia Krawczynska, Claire P Schane, Erin Weisser, Avni Singh and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Shruti V BendreDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0002-6391-8930
Yu WangDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Basel HajyousifDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0004-3604-9399
Rajendra K CCenter for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0006-1675-268X
Shounak G BhogaleDepartment of Computer Science, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Dhanya PradeepDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0002-7623-9734
Natalia KrawczynskaDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0002-1882-6009
Claire P SchaneDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0004-1752-8829
Erin WeisserDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Avni SinghDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Simon HanDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Hannah KimDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0006-3204-0834
Lara KockayaDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Anasuya Das GuptaDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0002-1273-0620
Adam T NelczykDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0001-7468-7835
Hashni Epa Vidana GamageDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0002-0743-2896
Yifan FeiDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0003-1493-8019
Desirée Rodríguez-CasianoDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Xingyu GuoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Haoyun LiDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0001-7634-4358
Ryan J DeatonResearch Histology and Tissue Imaging Core, University of Illinois Chicago, Chicago, IL, USA.
Fei MoResearch Histology and Tissue Imaging Core, University of Illinois Chicago, Chicago, IL, USA.ORCID 0009-0000-4020-2166
Maria SverdlovResearch Histology and Tissue Imaging Core, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0002-1893-865X
Peter H GannResearch Histology and Tissue Imaging Core, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0002-9439-2900
Saurabh SinhaDepartment of Computer Science, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0001-6033-7746
Sahil SahniLouis V. Gerstner Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0006-4678-3903
Kun WangDepartment of Comparative Biosciences, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Kevin Van BortleCancer Center at Illinois, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Emad TajkorshidBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0001-8434-1010
Wendy A WoodwardDepartment of Breast Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-7935-739X
Wonhwa ChoDepartment of Chemistry, University of Illinois Chicago, Chicago, IL, USA.
Erik R NelsonDepartment of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0002-8887-1905

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4M
Research Training Program in Toxicology and Environmental HealthT32ES007326 · NIEHS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jodi A. Flaws · 2000 to 2026
$8.7M
Supplement for Equipment for Lipid Regulation of Cellular Signaling and Protein-Protein InteractionsR35GM122530 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WONHWA CHO · 2017 to 2026
$6.1M
Training Program at the Chemistry Biology InterfaceT32GM136629 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Paul Hergenrother · 2020 to 2026
$4.5M
Deciphering the Mechanism of Lymphovascular Space Invasion Using a Lymphovascularized Bioengineering Breast Stromal PlatformR01CA284102 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI Bisrat G Debeb, Marissa Nichole Rylander · 2024 to 2026
$3.3M
Molecular Determinants of Inflammatory Breast CancerR01CA264529 · NCI · DUKE UNIVERSITY · PI DEVI, GAYATHRI · 2021 to 2025
$2.5M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
Translational Combinations of Nanocarriers and Blockers for Metastatic Breast CancerR01CA288207 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ERIK Russell NELSON, Andrew Michael Smith · 2024 to 2026
$1.7M
Impact of cholesterol and its metabolites on breast cancer progressionR01CA234025 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NELSON, ERIK RUSSELL · 2019 to 2023
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA234025NCI NIH HHS R01 CA264529NCI NIH HHS R01 CA284102NCI NIH HHS R01 CA288207NIBIB NIH HHS T32 EB019944NIEHS NIH HHS T32 ES007326NIGMS NIH HHS R35 GM122530NIGMS NIH HHS T32 GM136629
6 · The paper itself

Abstract

Breast and other solid tumors respond poorly to immune therapy. Myeloid cells (MCs) such as macrophages contribute to resistance. Established clinical evidence links cholesterol to cancer outcomes, with MC function being regulated by cholesterol metabolism. We screened MC-expressed regulators of cholesterol homeostasis linked to survival and identified the cholesterol efflux protein ABCA1. ABCA1 activity increases anticancer functions of macrophages: enhancing tumor infiltration, decreasing angiogenic potential, reducing efferocytosis, and improving support of CD8+ T cell activity. Mechanistically, different AKT isoforms are involved, through both PI3K-dependent and PI3K-independent mechanisms. Highlighting the clinical relevance of our findings are correlations between ABCA1 in macrophages and angiogenic potential,

Indexed as

ATP Binding Cassette Transporter 1CholesterolMyeloid CellsNeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMacrophagesMiceABCA1 protein, humanAbca1 protein, mouseATP Binding Cassette Transporter 1Cholesterol

Identifiers

PMID41477845
PMCPMC12757065

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.