Evidence map›Paper›PMID 41477859›Full record

ArticleScience advances2026

Circadian-shaped immune variability predicts infection outcome.

Jonathan Lalsiamthara, Mariko Locke, Alejandro Aballay

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonathan LalsiamtharaDepartment of Genetics, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.ORCID 0000-0001-5140-4599
Mariko LockeWestern University of Health Sciences, Lebanon, OR, USA.ORCID 0009-0005-9202-4935
Alejandro AballayDepartment of Genetics, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.ORCID 0000-0002-5975-3352

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disease risk and severity are influenced by genetics, epigenetics, and environmental factors. However, immune responses vary even among genetically similar or related individuals, shaped by inherited and noninherited factors. Using

Indexed as

Caenorhabditis elegansCircadian RhythmPseudomonas InfectionsAnimalsBiomarkersCaenorhabditis elegans ProteinsGene Expression RegulationMitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPseudomonas aeruginosaTranscription FactorsBiomarkersCaenorhabditis elegans ProteinsMitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPmk-1 protein, C elegansTranscription Factors

Identifiers

PMID41477859
PMCPMC12757043

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.