Evidence map›Paper›PMID 41478910›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Crowding Effects in RNA Interactions.

Francesco A Aprile, Annalisa Pastore

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesco A AprileDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK. f.aprile@imperial.ac.uk.
Annalisa PastoreInstitute of Brain Sciences, Burlington Danes, The Hammersmith Hospital, London, UK. annalisa.1.pastore@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular crowding refers to the excluded volume restriction of the space available to molecules in a solution due to the high concentration of other molecules, particularly macromolecules like proteins and nucleic acids. This restriction of space, or excluded volume effect, leads to changes in the behavior and properties of the crowded molecules. In this chapter, we discuss how RNA affects crowding and is affected by it and describe techniques that allow us to study these phenomena. We also discuss methods to extract granules that can then be used to understand their components.

Indexed as

RNARNABiochemistryBiophysicsConfinementCrowdingPhase separation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.