ArticleFrontiers in cellular and infection microbiology2025
The sociobiome-oral microbiome mediates dental caries among Indigenous Australians.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Signatures of the maternal-infant oral microbiome in contexts of imprisonment and social vulnerability.Frontiers in dental medicine · 2026Article
- Development and psychometric validation of the Psychosocial Impact of Dental Aesthetics Questionnaire for Australian Aboriginal and Torres Strait Islander adults.Australian journal of psychology · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: The sociobiome refers to the social and socioeconomic conditions that shape human microbial communities, linking structural inequities to biological changes in the microbiome. The aim of this study was to examine how individual and neighbourhood socioeconomic status (SES) are associated with the oral microbiota and dental caries in Indigenous Australian adults. Methods: This cross-sectional study involved 100 Indigenous Australian participants aged ≥ 18 years and was embedded within a decolonising, community-based participatory research framework. Demographic, socioeconomic, and oral health behaviour data were collected, followed by a dental examination and collection of saliva and plaque samples. The samples were analysed using 16S rRNA amplicon sequencing, and alpha and beta diversity, redundancy analysis, and differential abundance analysis were conducted. Mediation models were used to examine associations between income (Healthcare card ownership), education (≤ secondary), the oral microbiome, and dental caries. Results: The microbiome analyses showed saliva had higher alpha diversity (p < 0.01), and beta diversity was significantly different between saliva and plaque (adonis p < 0.001). In saliva, alpha diversity was lower with advancing age, secondary education, income, Healthcare card ownership, and dental caries presence. Beta diversity in saliva microbiome composition showed a stronger association with SES than plaque, with income source (R²=3.8%, Conclusion: Socioeconomic disadvantage is associated with variations in the oral microbiome, and these microbial patterns may explain the link between lower income and dental health caries. Saliva may serve as a sensitive biomarker of socioeconomic gradients in oral health. These findings support integrated approaches that address structural determinants of disadvantage alongside microbiome-informed preventive strategies when tackling oral health inequities in Indigenous populations.
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Registered trials
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