Evidence map›Paper›PMID 41479557›Full record

ArticleBrain, behavior, & immunity - health2026

Body talk: Correlates of gut-immune dysregulation phenotypes in people living with HIV who use methamphetamine.

Wilson Vincent, Annesa Flentje, Benjamin S Dominguez, Robert H Paul, Savita Pahwa, Suresh Pallikkuth, Margaret Roach, Dietmar Fuchs, Samantha E Dilworth, Torsten B Neilands and 5 more

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In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wilson VincentDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, Philadelphia, PA, 19122, USA.
Annesa FlentjeStanford Prevention Research Center, Stanford University, Stanford, CA, USA.
Benjamin S DominguezDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, Philadelphia, PA, 19122, USA.
Robert H PaulDepartment of Psychological Sciences, University of Missouri, St. Louis, USA.
Savita PahwaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
Suresh PallikkuthDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
Margaret RoachMiami Center for AIDS Research, University of Miami Miller School of Medicine, Miami, FL, USA.
Dietmar FuchsInstitute of Biological Chemistry, Medizinische Universität Innsbruck, Innsbruck, Austria.
Samantha E DilworthDepartment of Medicine, University of California, San Francisco, USA.
Torsten B NeilandsDepartment of Medicine, University of California, San Francisco, USA.
Peter W HuntDepartment of Medicine, University of California, San Francisco, USA.
Gowri SunderDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, Philadelphia, PA, 19122, USA.
Cody LentzDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, Philadelphia, PA, 19122, USA.
Sydney TelaakDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, Philadelphia, PA, 19122, USA.
Adam W CarricoDepartment of Health Promotion and Disease Prevention, Florida International University Robert Stempel College of Public Health and Social Work, Miami, FL, USA.

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
NIAID NIH HHS P30 AI073961
6 · The paper itself

Abstract

Background: Microbial translocation, immune activation, inflammation, and dysregulated metabolism of neurotransmitter precursors are interacting pathophysiologic processes linked to neuropsychiatric comorbidities and faster HIV disease progression. We examined correlates of distinct phenotypes of gut-immune dysregulation in people living with HIV (PWH) who use methamphetamine. Methods: Participants were 122 PWH who had biochemically confirmed recent methamphetamine use, including non-injection use. Peripheral plasma markers reflected: intestinal permeability, microbial translocation, immune activation, inflammation, and dysregulated metabolism of neurotransmitter precursors. Using latent profile analysis (i.e., clustering) of these markers, we identified gut-immune phenotypes and their clinical, demographic, and stigma-related correlates. Results: Three immune profiles emerged: (1) Conclusions: Distinct patterns of microbial translocation, immune activation, inflammation, and metabolism of amino acid precursors distinguished gut-immune phenotypes of PWH reporting injection methamphetamine use and greater internalized stigma. Interventions tailored to PWH who inject methamphetamine or struggle with internalized stigma could optimize HIV-related health outcomes.

Indexed as

HIVImmune dysregulationInjection drug useMethamphetamineMicrobial translocationStigma

Identifiers

PMID41479557
PMCPMC12753493

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.