ArticleWorld journal of gastrointestinal surgery2025
Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pleiotropic effects of statins, including anti-inflammatory and immunomodulatory actions, have prompted investigation into their perioperative role in colorectal cancer (CRC) surgery. However, findings remain inconsistent due to heterogeneity in study designs, statin regimens, and outcome definitions. This reviews current observational evidence, emphasizing the duration of statin therapy and its association with postoperative outcomes.
aimTo evaluate the association between statin therapy and postoperative outcomes in patients undergoing CRC surgery.
methodsA systematic literature search was conducted using PubMed and Google Scholar through March 2025. Five cohort studies evaluating statin use in CRC surgery were included. Primary outcomes assessed included anastomotic leak, surgical site infection, and 30-day and 90-day mortality. Data on statin duration and confounders such as comorbidities and surgical variables were also extracted.
resultsThree studies investigated the rates of anastomotic leaks in patients who used statins compared to those who did not. Two of the studies found no significant difference, while one noted a marginally higher leak rate among statin users. Diabetes, smoking habits, and operative time were found to be common confounding factors. Conversely, the use of statins was consistently linked to a decrease in 30-day mortality in propensity-matched groups, although findings regarding 90-day mortality were variable.
conclusionStatin therapy may confer short-term survival benefits in CRC surgical patients, potentially
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.