SynthesisFrontiers in neuroscience2025
Effects of transcranial direct current stimulation on non-motor functions in individuals with Parkinson's disease: a systematic review and meta-analysis.
Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is a highly prevalent neurodegenerative disorder that poses a significant mental and physical burden on patients, markedly diminishing their quality of life. This study aimed to systematically evaluate the effects of transcranial direct current stimulation (tDCS) on cognitive functions, mood state, sleep function, and overal quality of life in individuals with PD. Methods: Relevant literature was sourced from multiple databases, ultimately including 22 studies with a total of 1324 individuals. Data analysis was conducted using meta-analysis software. The protocol was registered in PROSPERO (CRD42024599943). Results: The findings indicated that tDCS significantly enhanced cognitive function, alleviated anxiety and depression, increased sleep duration, improved sleep efficiency, reduced arousal index, and ameliorated daytime sleepiness, while also enhancing activities of daily living. However, discrepancies were noted across various assessment scales, including the Mini-Mental State Examination, the Parkinson's Disease Cognitive Rating Scale, delayed recall metrics, sleep scales, and Parkinson's Disease Questionnaire. Additionally, individuals with PD displayed good tolerance to tDCS. Conclusion: Overall, tDCS shows promise in improving non-motor symptoms and enhancing quality of life for individuals with PD. Nonetheless, large-scale trials are necessary to confirm these results further. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024599943, Identifier: CRD42024599943.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.