ArticleWorld journal of nephrology2025
Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country.
Article in World journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundImmunoglobulin A nephropathy is a leading cause of primary glomerulonephritis globally. Predicting disease progression using clinical markers alone is often inadequate. Integrating the Oxford classification may enhance kidney survival predictions, though its relevance in Pakistan remains unexplored.
aimTo determine the correlation between MEST-C scores and clinical parameters, as well as their utility in predicting long-term kidney outcomes.
methodsA retrospective analysis was conducted on biopsy-confirmed immunoglobulin A nephropathy cases diagnosed from 1998 to 2019 at the Sindh Institute of Urology and Transplantation, with a minimum follow-up of 12 months.
resultsAmong 118 patients (mean age: 29.03 ± 10.58 years), median proteinuria was 2.13 g/day, and mean estimated glomerular filtration rate (eGFR) was 67.82 ± 44.60 mL/minute/1.73 m
conclusionThe E1, T1/2, and C1/C2 components of the MEST-C score showed strong correlations with baseline clinical markers. Delayed diagnosis has led to poor long-term kidney outcomes.
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