ReviewFrontiers in immunology2025
Targeting persistently activated inflammatory microenvironment to promote chronic wound healing.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Next-generation skin wound healing related disease models with integration of immune cells.Protein & cell · 2026Review
- Preparation of Multifunctional Hydrogel Loaded with Isochlorogenic Acid A/FeGels (Basel, Switzerland) · 2026Article
- Review
- Pro-Inflammatory Cytokines as Core Mediators of Colonic Epithelial Barrier Dysfunction: Roles of TNF-α, IFN-γ, IL-1β, and IL-6.International journal of molecular sciences · 2026Review
- Oral squamous cell carcinoma is associated with altered salivary microbiome structure and reduced community evenness.Scientific reports · 2026Article
- The Potential of a Graphene Monolayer in Macrophage Polarization Using RAW 264.7 Cells.Journal of functional biomaterials · 2026Article
- Endogenous Bioelectrical Modulation of Longevity-Associated and Inflammatory Signaling Pathways in Human Dermal Fibroblasts Following the REAC ACT-IBZ Protocol.Life (Basel, Switzerland) · 2026Article
- Neuroimmune regulation of post-traumatic bone regeneration: focus on inflammatory switching and functional recovery.Frontiers in immunology · 2026Review
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
- Serum amyloid A in the oral microenvironment: implications for inflammation, host-microbe interactions, and disease monitoring.Frontiers in immunology · 2026Review
- Electrochemical modulation of host-microbe dynamics in wound healing.Frontiers in microbiology · 2026Review
- Orchestrating the gut microbiota-mitochondrial-immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies.Frontiers in reproductive health · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system plays a pivotal role in maintaining the balance of inflammatory responses and facilitating tissue repair and wound healing. However, under the combined influence of immune microenvironmental factors and external stimuli, immune cell dysfunction can lead to persistent activation of the inflammatory milieu, resulting in delayed or impaired wound healing. Therefore, regulating immune responses within the chronic inflammatory microenvironment and suppressing aberrant immune cell activation not only helps restore immune homeostasis but also effectively accelerates the wound healing process. Identifying and modulating novel targets associated with macrophage and T-cell dysregulation, as well as the crosstalk among immune cells, offers new insights and therapeutic strategies for the treatment of chronic inflammation-related disorders and wound repair. This review focuses on the molecular mechanisms underlying aberrant macrophage and T-cell activation, the intercellular crosstalk within the immune microenvironment, and their impact on the wound healing process. Furthermore, it highlights potential therapeutic targets for limiting persistent inflammation and re-establishing immune homeostasis. Elucidating these mechanisms and targets may provide promising avenues for the treatment of chronic inflammatory diseases and for advancing strategies in tissue repair and regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.