ArticleFrontiers in immunology2025
Lactate attenuates PANoptosis and enhances ZBP-1 lactylation in macrophages in acute lung injury.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Autophagy determines the fate of immune cells by regulating metabolic remodeling and PANoptosis (Review).International journal of molecular medicine · 2026Review
- Lactylation and regulated cell death: the substrate defines the outcome.Apoptosis : an international journal on programmed cell death · 2026Article
- The landscape of protein post-translational modifications in the pathogenesis of acute respiratory distress syndrome.Journal of thoracic disease · 2026Review
- Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion.Oncogene · 2026Article
- Review
- Lactate and lactylation in sepsis: regulation of immune-metabolic crosstalk and organ injury.Frontiers in immunology · 2026Review
- Neutrophil-macrophage crosstalk network in acute lung injury: feedback circuits linking cytokine storm and cell death.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Introduction: Acute lung injury (ALI), characterized by excessive inflammation and cell death, is closely associated with ZBP1-mediated PANoptosis, a programmed cell death mechanism. The intrinsic regulatory mechanism of PANoptosis remains poorly investigated. Methods: In this study, we investigated the protective effects of lactate on lipopolysaccharide (LPS)-induced ALI and its potential regulatory role in ZBP1-mediated PANoptosis. Results: Our results showed that lactate effectively reduced inflammatory cytokine (TNF-α, IL-6, and IL-1β) and CD11b Conclusion: The present study revealed the regulatory role of lactate in inflammation and cell death in ALI and suggested a lactylation-associated therapeutic strategy for ALI.
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