Evidence map›Paper›PMID 41479922›Full record

ReviewFrontiers in immunology2025

Novel regulators of hepatic macrophages in liver fibrosis.

Xiangjun Tang, Meiwen Bai, Xianhong Du, Hong Wang, Meifang Liu, Xiaoyan Fu, Hongxia Zhang, Shujuan Liang, Liyuan Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Liver Macrophages in the Pathogenesis of Viral Hepatitis.Current issues in molecular biology · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangjun Tang *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Meiwen Bai *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Xianhong Du *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Hong WangKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Meifang LiuKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Xiaoyan FuKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Hongxia ZhangKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Shujuan LiangKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.
Liyuan WangKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis is a common pathological process resulting from liver damage and subsequent inflammatory responses in various chronic liver diseases, leading to persistent structural and functional abnormalities in the liver. It can further progress to liver cirrhosis and hepatocellular carcinoma. Currently, no effective treatments are available for liver fibrosis, except for liver transplantation. Hepatic macrophages play essential roles in both the development and regression of liver fibrosis. Understanding the mechanisms by which hepatic macrophages regulate liver fibrosis could identify new therapeutic targets. In this review, we aim to summarize recent discoveries regarding the specific molecular mechanisms underlying the progression of liver fibrosis over the past 5 years, with a special focus on monocyte recruitment and macrophage polarization or differentiation, as well as their roles in disease progression.

Indexed as

LiverLiver CirrhosisMacrophagesAnimalsCell DifferentiationDisease ProgressionHumansMacrophage Activationliver fibrosismacrophagemacrophage polarizationmolecular mechanismsmonocyte recruitment

Identifiers

PMID41479922
PMCPMC12754181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.