ReviewMechanobiology in medicine2026
Mechanoimmunology: past, present, and future perspectives.
Review in Mechanobiology in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Substrate pre-stretch reprograms macrophage behavior through surface topographical remodeling.Mechanobiology in medicine · 2026Article
- The mechano-immunological landscape in the tumor microenvironment: From mechanical sensing to a new therapeutic paradigm.Materials today. Bio · 2026Review
- Mechanobiological research fueling the advancement of mechanotherapy and mechanohealth.Mechanobiology in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The immune system relies on intricate molecular interactions and cellular signaling to discriminate between self and non-self, mount appropriate responses to pathogens and cancer, and maintain tissue homeostasis to avoid autoimmune diseases. Evidence increasingly supports the critical role of mechanical forces in regulating immune cell function and differentiation through immunoreceptor interactions with immobilized ligands, leading to the emerging interdisciplinary field of mechanoimmunology. This review delves into the historical development and recent advances of the field. We highlight the key concepts and questions in understanding how immune cells perceive and respond to mechanical cues, with a focus on the critical role of catch bonds in immunoreceptor-mediated mechanotransduction and explore their immunotherapeutic applications. Furthermore, we explore the profound implications of mechanoimmunology for understanding major immunological problems and its potential applications in advanced immunotherapies and regenerative medicine.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.