SynthesisFrontiers in public health2025
The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Preconception exposures of female mice to a panel of metabolic disruptors induce sexually dimorphic metabolic perturbations in their offspring.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Health behaviors and exposures to environmental hazards among individuals of reproductive age prior to pregnancy can influence maternal and child health outcomes. While research attention has focused on preconception health behaviors, such as diet and lifestyle, there is emerging evidence that environmental exposures may also be important to consider. Methods: A search strategy (PROSPERO # CRD42021240069) was developed for MEDLINE (OVID), EMBASE (OVID), Maternity and Infant Care (OVID), CINAHL (EBSCO), and PsycINFO (EBSCO). Searches were conducted from database inception until 21 May 2021. Studies were included that investigated male or female exposure to any environmental hazard during the preconception period and reported neonatal or child health outcomes. No limit to date of publication, language or comparator were applied. Studies were critically appraised using the Newcastle-Ottawa Quality Assessment Scale for Cohort studies. Results: The review identified 63 studies that met the inclusion criteria, published between 1974 and 2021. They encompassed studies that covered ambient exposures ( Discussion: There is growing evidence of adverse outcomes in offspring associated with maternal and paternal environmental exposures during the pre-conception period. While there are some topics that have received focused attention from research teams in the last 50 years, most studies appear to be standalone and have not continued to develop as part of wider research programs. There is need to develop a field-wide approach to create an agenda for environmental preconception health exposures and outcomes that supports more coordinated, targeted and strategic research efforts. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42021240069.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.