Evidence map›Paper›PMID 41480394›Full record

ReviewWorld journal of stem cells2025

Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions.

Han Li, Zhi-Peng Li, Meng-Ting Zhu, Chen-Hao Lan, Yu-Xin Wang, Ping Liao, Zheng Chen, Peng Wang, Jin-Ke Sun, Zhen Shi and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Han LiDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Zhi-Peng LiSecond Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Meng-Ting ZhuDepartment of Neurology, Union Medical College Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China.
Chen-Hao LanDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Yu-Xin WangDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Ping LiaoDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Zheng ChenDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Peng WangSecond Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Jin-Ke SunThird Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Zhen ShiSecond Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Peng-Yu LuFirst Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Chao LouDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China.
Guo-Hong XuDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China. xgh316@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon-bone healing remains a significant clinical challenge due to the high risk of re-rupture following injury. While mesenchymal stem cells (MSCs) show great potential in enhancing tendon-bone healing, their clinical application is limited by issues such as low delivery efficiency, restricted differentiation potential, and potential immunogenicity. Recently, various strategies combining MSCs with other approaches, such as preconditioning, biomaterial integration, gene modification, and exosome application, have been developed, resulting in improved therapeutic outcomes. This review explored the current methods used to optimize MSC therapy for tendon-bone healing, examining the advantages, disadvantages, and underlying mechanisms of each approach, providing a foundation for future research and clinical applications.

Indexed as

BiomaterialsExosomesGene modificationMesenchymal stem cellsPreconditioningTendon-bone healing

Identifiers

PMID41480394
PMCPMC12754425

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.