Evidence map›Paper›PMID 41480405›Full record

ArticleBioactive materials2026

Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtDNA.

Shiyu Li, Zi Yan, Xinwang Zhi, Weihan Zheng, Ziqi Zhang, Zhenning Dai, Wanying Chen, Hui Lu, Ziyi Feng, Ting Cheng and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shiyu LiDepartment of Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Zi YanDepartment of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Xinwang ZhiDepartment of Pediatric Orthopedics, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 511436, China.
Weihan ZhengThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China.
Ziqi ZhangBiliary and Pancreatic Surgery of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Zhenning DaiDepartment of Stomatology, Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, 510095, China.
Wanying ChenDepartment of Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Hui LuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Ziyi FengSchool of Stomatology, Jinan University, Guangzhou, 510632, China.
Ting ChengInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Wenhui LiuThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China.
Baoyu SunInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Yuhai MaDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Bing ZhangEngineering Research Center of Techniques and Instruments for Diagnosis and Treatment of Congenital Heart Disease, Institute of Developmental and Regenerative Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Jianyuan ZhaoMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Han LiuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan SuDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infrapatellar fat pad mesenchymal stem cells (IPFP-MSCs) extracellular vesicles (EVs) are found to be capable of accelerating Osteoarthritis (OA) progression. However, which pathways and which pathogenic EVs subgroups are involved are not defined. In our study we found that there were a higher percentage of TOMM20

Indexed as

cGAS-STINGExtracellular vesiclesInfrapatellar fat padMitochondria-derived vesiclesMitochondrial dysfunctionmtDNAOsteoarthritis

Identifiers

PMID41480405
PMCPMC12754226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.