SynthesisFrontiers in cardiovascular medicine2025
Association of inflammatory markers with clinical outcomes in atrial fibrillation: a meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- The association between albumin/neutrophil-to-lymphocyte ratio score and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database.Journal of thoracic disease · 2026Article
- Development and validation of an interpretable machine learning model for predicting atrial fibrillation risk in middle-aged and older patients with coronary heart disease.Frontiers in cardiovascular medicine · 2026Article
- Predictive value of the monocyte-to-high-density lipoprotein cholesterol ratio in atrial fibrillation: a meta-analysis.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammatory markers are increasingly recognized as key contributors to the pathogenesis and progression of atrial fibrillation (AF). This meta-analysis aims to systematically assess the prognostic significance of various lymphocyte-based inflammation indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) with clinical outcomes in AF. Methods: A comprehensive search was conducted in multiple databases until March 24, 2024. The included studies evaluated lymphocyte-based indices in relation to AF prognosis using a random-effects model. Weighted Mean Differences, Hazard ratios, and Odds Ratios with 95% Confidence Intervals were calculated. Subgroup and sensitivity analyses were performed, and evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Results: Twenty-one studies involving 63,687 patients with AF were included. Higher NLR was associated with increased risks of all-cause mortality (HR: 1.50, 95% CI: 1.16-1.92; Conclusion: Higher NLR shows an observational association with adverse outcomes in AF, but the certainty of evidence is low. Evidence for PLR and SII is extremely limited and inconsistent, precluding meaningful conclusions. Further large, well-designed prospective studies with standardized measurements are required. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024540368, identifier CRD42024540368.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.