ArticleWorld journal of diabetes2025
Effect of fish scale ointment on diabetic foot ulcer by inducing ferroptosis
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Advances and Challenges in the Comprehensive Management of Diabetic Foot: A Narrative Review from a General Practice Perspective.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
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7 authors.
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Abstract
backgroundExcessive oxidative stress plays a key role in the development of diabetic complications, including impaired ulcer healing. Previous studies have shown that fish scale ointment can promote wound healing.
aimTo preliminarily investigate the effect of fish scale ointment on wound healing in a diabetic foot ulcer (DFU) rat model by examining its regulation of the nuclear factor E2-related factor 2 (Nrf2) pathway and induction of ferroptosis.
methodsFish scale ointment (collagen product) was prepared from 500 g of silver carp scales. A diabetic rat model was induced by high-fat and high-sugar feeding combined with intraperitoneal streptozotocin injections. For the DFU rat model, ulcer wounds were created by removing dorsal foot hair and cutting the skin to the fascia. The diabetic rats were randomized into five groups: Model, fish scale collagen (FSC), control + liproxstatin-1 (Lip-1), model + Lip-1, and FSC + Lip-1. In each group, treatments were administered once daily by topical application and intraperitoneal injection for 14 days. Wound healing was evaluated on days 7 and 14 after treatment. Hematoxylin and eosin staining was used to assess wound injury and capillary formation. Basic fibroblast growth factor (bFGF) and CD31 levels in wound tissue were measured by immunohistochemistry. Additionally, malondialdehyde (MDA), glutathione (GSH), ferroptosis-associated genes, and iron ion concentrations were quantified using assay kits. Protein levels of Nrf2, heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (GPX4) were determined using Western blotting.
resultsCompared with the control group, the model group showed slower wound healing, reduced angiogenesis, decreased bFGF and CD31 levels, increased iron ion concentration and MDA levels, reduced GSH levels, and decreased Nrf2, HO-1, and GPX4 protein expression (all
conclusionFish scale ointment promotes angiogenesis and wound healing in DFU rat models by inhibiting ferroptosis, possibly through the activation of the Nrf2 pathway.
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