Evidence map›Paper›PMID 41481412›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

From bench to brain: novel thieno-oxazine hybrids as potent pleiotropic anti-Alzheimer's agents with

Eman A Fayed, Mazin A A Najm, Khulood H Oudah, Maha A Ebrahim, Nirvana A Gohar, Karema Abu-Elfotuh, Ehsan Khedre Mohamed, Ahmed M E Hamdan, Najla A Albalawi, Shahad Faisal Alzahrani and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eman A FayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Mazin A A NajmDepartment of Pharmacy, Mazaya University College, Nasiriyah, Iraq.
Khulood H OudahDepartment of Pharmacy, Mazaya University College, Nasiriyah, Iraq.
Maha A EbrahimDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Nirvana A GoharDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
Karema Abu-ElfotuhDepartment of Clinical Pharmacy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Ehsan Khedre MohamedDepartment of Biochemistry, Egyptian Drug Authority (EDA), formerly National Organization of Drug Control and Research (NODCAR), Giza, Egypt.
Ahmed M E HamdanDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Najla A AlbalawiFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Shahad Faisal AlzahraniFaculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Amira M HamdanOceanography Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Reema AlmotairiPrince Fahad Bin Sultan Chair for Biomedical Research (PFSCBR), University of Tabuk, Tabuk, Saudi Arabia.
Shaimaa M HafezDepartment of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Triveena M RamsisDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Ismailia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to their various pharmacological effects, several substituted sulphur heterocycles containing thiophene have recently attracted a great deal of attention. A novel 2,3-diaryl-2,3,5,6,7,8-hexahydro-4

Indexed as

Alzheimer DiseaseBrainCholinesterase InhibitorsOxazinesThiophenesAcetylcholinesteraseAnimalsButyrylcholinesteraseDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsOxazinesThiophenesAChE and BChE inhibitorsADMET and docking studiesAlzheimer’s diseasemulti-targets and histopathological examinationsThieno-oxazines

Identifiers

PMID41481412
PMCPMC12777904

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.