Evidence map›Paper›PMID 41482500›Full record

ArticleJournal of applied clinical medical physics2026

Clinical experience with a same-day simulation and treatment program for stereotactic radiation therapy on a C-arm linac.

Michalis Aristophanous, Sernger Shen, Dylan G Hsu, Dongxu Wang, Ase Ballangrud, Jean M Moran, Anyi Li, Sean M McBride, Daniel Gomez, Luke R G Pike and 3 more

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michalis AristophanousDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-9117-1515
Sernger ShenDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dylan G HsuDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-9045-5049
Dongxu WangDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ase BallangrudDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jean M MoranDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-9668-7326
Anyi LiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sean M McBrideDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Daniel GomezDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Luke R G PikeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kathryn BealDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jonathan T YangDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Laura CervinoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeWe report our experience with the implementation of a same-day simulation and treatment C-arm linear accelerator (linac)-based stereotactic program for patients with intracranial and extracranial metastatic disease.

methodsBetween May 2021 and October 2023, patients were treated in our same-day program with linac-based SRS/SBRT. Two slots per week were offered. Patients with expedited clinical needs, able to undergo SRS/SBRT simulation and treatment, were considered. Extracranial treatments were required to meet standards for automated intensity modulated radiation therapy (IMRT) optimization. Intracranial treatments were limited to 1-3 lesions and 1-2 isocenters. The day before treatment, the patient needed to be identified, and any diagnostic imaging had to be available for the physician and dosimetrist to discuss the plan. On the day of treatment, simulation was scheduled for 8 AM and treatment at 4 PM by default, with the goal to complete treatment by 6 PM. We analyzed information about each patient's treatment plan and time spent on each step of the workflow.

resultsNinety-seven patients followed our same-day workflow and were included in the analysis. Seventy-five patients received intracranial SRS (57% to 1 lesion), while 22 patients received extracranial treatments (50% to the extremities). Simulation often required additional time to be completed, finishing a median 18 min (IQR 5-40) after the goal end time. The median time between simulation completion and end of the same-day treatment was 7.8 h (IQR 7.4-8.6). Treatment technique and the number of target volumes had a significant impact on planning time. The median treatment end time was 5:13 PM (IQR 4:46 PM-6:01 PM), with 74% ending by 6 PM.

conclusionsA linac-based program to treat patients with SRS/SBRT in an expedited fashion was established and successfully treated patients in a same-day timeline. Careful selection of planning techniques to limit plan complexity and adding automation in time-consuming parts of the process are crucial when developing expedited workflows.

Indexed as

Brain NeoplasmsParticle AcceleratorsRadiosurgeryRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedAgedComputer SimulationFemaleHumansMaleMiddle AgedOrgans at RiskRadiotherapy DosageWorkflowsame‐daySBRTSRS

Identifiers

PMID41482500
PMCPMC12758992

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.