ArticleFunctional & integrative genomics2026
LEC2, a key player for cell totipotency in somatic embryogenesis and plant regeneration.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Totipotency, the capacity of a single cell to regenerate a complete organism, is the central to plant developmental plasticity and underpins plant regeneration via somatic embryogenesis and/or organogenesis, a cornerstone of plant biotechnology, including transgenics and genome editing. A recent study, by using time-resolved single-cell and spatial transcriptomic analysis, Tang et al. 2025 shows that LEAFY COTYLEDON2 (LEC2) can reprogram a defined epidermal lineage, SPEECHLESS (SPCH)-expressing meristemoid mother cells (MMCs), into somatic embryo founder cells (SEFCs) by cooperating with SPCH to activate local auxin biosynthesis (TAA1/YUC4), producing a GMC-auxin transitional state that enables transcriptional and chromatin reconfiguration toward totipotency. This lineage-specific, auxin-driven route both refines conceptual models of plant reprogramming and offers practical levers to improve plant regeneration and transformation in crops.
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