Evidence map›Paper›PMID 41483439›Full record

SynthesisDigestive diseases and sciences2026

Risk Factors of Post-ESD Electrocoagulation Syndrome for Colorectal Neoplasms: A Systematic Review and Comprehensive Meta-Analysis.

Aamir Saeed, Matthew David McGowin, Seth Weiss, Ijlal Akbar Ali, Maham Hayat, Samuel Igbinedion, Mark Radlinski, Sultan Mahmood, Faisal Kamal

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aamir SaeedDivision of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, 920 Madison Avenue, Memphis, TN, 38163, USA. aamirsaeed4444@gmail.com.
Matthew David McGowinDivision of Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Seth WeissDivision of Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Ijlal Akbar AliDivision of Gastroenterology, The University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Maham HayatCenter for Interventional Endoscopy, AdventHealth Orlando, Florida, USA.
Samuel IgbinedionDivision of Gastroenterology, The University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Mark RadlinskiDivision of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sultan MahmoodDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, USA.
Faisal KamalDivision of Gastroenterology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic submucosal dissection (ESD) has gained increasing popularity in the management of complicated colorectal polyps. Post-ESD electrocoagulation syndrome (PECS) has been recognized as one of the significant complications. Several studies have evaluated different risk factors associated with post-endoscopic submucosal dissection electrocoagulation syndrome for colorectal neoplasms. In this meta-analysis, we aimed to identify the risk factors of PECS after colorectal ESD.

methodsA comprehensive literature search of PubMed, Embase, Web of Science Core Collection, and the Cochrane Database for Systematic Reviews was conducted from inception to February 05, 2025. All studies that used a multivariate model to assess risk factors for post-ESD electrocoagulation syndrome were included. Pooled odds ratios (OR) with 95% confidence intervals (CI) for risk factors reported in ≥ 2 studies were obtained within a random-effects model.

resultsNineteen studies (3 prospective, 2 RCTs, 14 retrospective studies) with 8151 patients who underwent endoscopic submucosal dissection for colorectal lesions were included. Pooled Incidence of PECS was 8.9%. Ten different risk factors were analyzed. Meta-analysis demonstrated that female gender OR 3.03 (2.16, 4.24), tumor size ≥ 20 mm OR 2.57 (1.65, 3.99), procedure time ≥ 60 min OR 2.25 (1.33, 3.79), tumor location in right sided colon OR 3.33 (1.85, 5.99), submucosal fibrosis OR 3.34 (1.65, 6.75), injury to muscle layer high OR 5.43 (3.04, 9.67) and high joule heat accumulation OR 10.01 (2.83, 35.40) were significant predictors of Post-ESD electrocoagulation syndrome. Older age ≥ 60 years, lesions in the left-sided colon (rectosigmoid), traction-assisted ESD, Tumor morphology LST-G type, non-lifting, and deep submucosal invasions were not significant risk factors in post-ESD electrocoagulation syndrome.

conclusionThis meta-analysis demonstrates that female sex, lesion size ≥ 20 mm, procedure time ≥ 60 min, right-sided location, submucosal fibrosis, muscle layer injury, and high Joule heat accumulation were associated with increased odds of PECS. Understanding these risk factors can help clinicians identify patients at higher risk of PECS and implement preventive measures to improve outcomes after colorectal ESD.

Indexed as

Colorectal NeoplasmsElectrocoagulationEndoscopic Mucosal ResectionPostoperative ComplicationsFemaleHumansRisk FactorsSyndromeColorectal neoplasmDeep submucosal invasionElectrocoagulation syndromeEndoscopic submucosal dissectionPredictorsRisk Factors

Identifiers

PMID41483439

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.