Trial reportScientific reports2026
Exercise induces structural brain changes and elevates irisin levels and enhances functional performance in multiple sclerosis a pilot randomized study.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Assessment of Changes in Postural Stability and Load Distribution in Patients With Multiple Sclerosis After 12 Weeks of Self-Paced Exercises Programmed by a Physiotherapist: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise may promote neuroprotection in multiple sclerosis (MS), but the relationships between exercise-induced brain changes, myokine release, and functional improvements are not fully understood. This pilot randomized controlled trial examined the effects of a 12-week progressive resistance training (PRT) program on brain structure, serum irisin levels, and functional performance, measured with the MS functional composite (MSFC), (PRT: *N*=11; control: *N*=10). The PRT group demonstrated increased serum irisin and enhanced motor and cognitive function, including faster walking speed, improved manual dexterity, and better processing speed. Neuroimaging revealed volumetric increases in gray matter, cerebellum, hippocampus, temporal lobe, and caudate nucleus following PRT. Compared to controls, the exercise group showed greater improvements in irisin levels, mobility, and regional brain volumes, particularly in gray matter, cerebellum, and temporal and hippocampal regions. Correlations were observed between cerebellar and frontal lobe volume changes and cognitive gains, while occipital lobe expansion was linked to fine motor improvements. However, no direct association was found between irisin elevation and brain structural changes. These results suggest that PRT induces concurrent neuroplastic adaptations and functional benefits in MS, though the role of irisin may involve mechanisms beyond volumetric effects. Resistance training represents a viable non-pharmacological strategy to support brain health and functional outcomes in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.