ArticlePsychophysiology2026
Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.
Article in Psychophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The developmental shift in aperiodic activity and its link to the default mode network in attention-deficit hyperactivity disorder.Psychological medicine · 2026Article
- Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.Psychophysiology · 2026Article
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5 authors.
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Abstract
The power spectrum derived from electroencephalography (EEG) recordings has been shown to include both periodic (e.g., delta, theta, alpha, beta) and aperiodic (e.g., 1/f exponent shape, vertical offset) components. Although internalizing disorders have been characterized by alterations in several periodic EEG measures, aperiodic activity has typically been treated as noise and unexamined in clinical neuroscience. Importantly, recent evidence has shown that aperiodic activity may reflect fundamental biological constructs such as excitatory-inhibitory (E-I) neural balance and neuronal cell spiking which are implicated in internalizing disorders. While previous research has found some evidence for blunted aperiodic parameters in adults with depression, few studies have probed the association between anxiety symptoms and aperiodic activity, and no work has probed these associations in adolescence when both mood and anxiety disorders commonly onset. Here, adolescents with current depressive disorders (n = 53), at high risk for depression due to maternal depressive history (n = 49), and at low risk for depression due to no maternal or personal depressive history (n = 51) completed an eyes-closed resting state EEG paradigm to estimate aperiodic parameters. No group differences in aperiodic activity were observed, but age-related declines in aperiodic exponent were moderated by depressive diagnosis such that those with a current depressive disorder diagnosis showed a steeper decline in the aperiodic exponent with age. Further, age-related declines in aperiodic activity were moderated in opposite directions by internalizing symptoms such that elevated depressive symptoms steepened the inverse association between aperiodic activity and age, while elevated anxiety symptoms weakened this association. Results suggest unique alterations of aperiodic activity with internalizing symptoms and highlight the importance of considering aperiodic activity as a unique construct from periodic activity in investigating internalizing symptoms and brain development.
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