Evidence map›Paper›PMID 41484550›Full record

ArticleBMC genomics2026

The hybridization analysis of pedigree: whole-genome re-sequencing reveals genomics characterization and genetic basis of growth trait of Qinchuan black pigs.

Minghao Cao, Tiantian Yuan, Dong Li, Xiang Li, Yanyan Huang, Jingchun Sun, Yulong Wang, Taiyong Yu

Abstract read
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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Minghao Cao *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0009-0003-2969-0551
Tiantian Yuan *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0009-0002-3741-0006
Dong LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0002-7765-469X
Xiang LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0009-0009-6746-3580
Yanyan HuangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Jingchun SunKey Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.ORCID http://orcid.org/0000-0002-3284-7973
Yulong WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0009-0002-0055-388X
Taiyong YuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition & Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. yutaiyong310@nwsuaf.edu.cn.ORCID http://orcid.org/0000-0001-6951-9968

Funding

National Key Research and Development Program of China 2021YFD1301200
6 · The paper itself

Abstract

backgroundUnderstanding the genetic basis of hybridization trait between Chinese indigenous pig and their commercial relatives may contribute to germplasm innovation. The Qinchuan black (QCB) pig is a new composite breed under development generated from Chinese indigenous pig breeds (i.e., Guanzhong black pig, GZB) and intensive pig breeds (i.e., Yorkshire, also called Large white pig, LW). Investigated gene functions inherited from parent help us to understand the genetic basis of excellent phenotype similar with their parents, in which parents correspond to grandparents for hybrid population in our study.

resultHere, we performed population structure and admixture analyses to elucidate the genetic position of QCB among Asian and European pig breeds. Ancestral track analysis revealed the LW contributed more genomic components in QCB genome, particularly on chromosome 7. This asymmetric inheritance may be influenced by linkage disequilibrium blocks. The offspring genome exhibited high genetic diversity, as did its maternal genome (GZB). Both genomes were characterized by a reduced number and shorter length of Run of Homozygosity (ROH). Finally, we used HKA test to investigated key gene in QCB that were inherited from its parents and that regulate important economic traits. Our results identified a significant association between an NPC1L1 haplotype inherited from the LW genome and body weight in four-month-old QCB.

conclusionOur research provides a novel strategy for utilizing previously identified functional loci or genes to guide the breeding of domestic pig for improvement economic traits in crossbreeding systems.

Indexed as

GenomicsHybridization, GeneticPedigreeWhole Genome SequencingAnimalsBreedingFemaleLinkage DisequilibriumPhenotypePolymorphism, Single NucleotideSwineGene inherited parentHybridization breedingMining germplasm resourceQinchuan black pig

Identifiers

PMID41484550
PMCPMC12952159

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.